In today’s world, narcotics and its related business such as drug precursors play a pivotal role in the relations among states and politicians. The huge financial cycle in the narcotics market has paved the way for corruption among high-ranking, international policymakers and politicians at high levels across the globe. Nobody can deny the high costs the narcotics business imposes on different communities; in the meanwhile, some Western politicians have put the expansion of this business at the top of their agendas with the purpose of extending their influence in developing countries. Large portion of these drugs find their way through the international market from a number of trafficking routes, with the prominent ones running over Iranian soil. This growing threat cannot be overlooked, and Iran’s blocking and interdiction role can no longer be underestimated. In our documentary “The Front Line”, the production, distribution, and consumption cycle of narcotics in the Middle East, with a particular focus on Afghanistan and Iran, are analyzed through conducting interviews with experts and political analysts, providing useful, informative data and figures about the issue, and putting into perspective the real players, philosophies, and policies behind this sophisticated business and its development. The main issues discussed include: the role of Afghanistan and neighboring countries in the narcotics cycle, Iran’s international and extraterritorial measures to prevent the expansion of the narcotics business, as well as the attempts and strategies put forward by Iran to confront the narcotics issue in the country. Iran plays a pivotal role in the war against drugs. Despite high economic and human costs, the Islamic Republic has been actively fighting drug trafficking over the past three decades.